一、基本信息
乔嘉璐，博士，副教授，硕士生导师
电子邮件： jialuqiao@hubu.edu.cn
研究领域： RNA病毒与宿主互作机制研究，抗病毒防控策略和干预技术研究
研究团队：必赢唯一官方网站病毒学和疫苗研究中心，陈明周教授课题组，链接： /info/2059/16972.htm
二、教育背景
2012.09–2019.06 武汉大学，微生物学，博士
2008.09–2012.07 山西大学，生物科学，学士
三、工作经历
2024.05至今 必赢集团网站，副教授
2019.07–2024.04 江汉大学医学院，讲师，副教授
四、主持科研项目
1. 国家自然科学基金委员会, 青年科学基金项目（32100131）, SARS-CoV-2非结构蛋白Nsp5与Bcl2相互作用诱导线粒体损伤激活NLRP3炎症小体的分子机制研究, 2022-01至 2024-12, 主持
2. 武汉市教育局, 武汉市产学研项目（CXY202204）, 多靶点抗SARS-CoV-2小分子化合物的鉴定及开发, 2022-11至2024-12, 主持
3. 武当特色中药研究湖北省重点实验室开放课题，重点项目（WDCM2022008），抗SARS-CoV-2入侵的武当特色中药筛选及其机制研究，2022-06至2023-06, 主持
4. 武汉市科学技术局, 应用基础前沿专项（2020020601012318），抑制SARS-CoV-2 感染细胞的海洋微生物多糖鉴定研究, 2020-08 至 2022-12,，主持
五、代表性论文（#第一作者; *通讯作者）
第一作者或通讯作者文章
1. Jing Yang#; Donghui Jia#; Jialu Qiao#; Ximing Peng; Chuchao Zhou; Yanqing Yang，Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel. International Journal of Nanomedicine 19 (2024) 11499-11516.
2. C. Wang, X. Ye, C. Ding, M. Zhou, W. Li, Y. Wang, Q. You, S. Zong, Q. Peng, D. Duanmu, H. Chen, B. Sun, and J. Qiao*, Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry. J Agric Food Chem 71 (2023) 5535-5546.
3. S. Zong, Y. Wu, W. Li, Q. You, Q. Peng, C. Wang, P. Wan, T. Bai, Y. Ma, B. Sun, and J. Qiao*, SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria. Virol Sin 3 (2023) 520-530.
4. W. Li#, J. Qiao# K. Lin, P. Sun, Y. Wang, Q. Peng, X. Ye, W. Liu, and B. Sun, Ethyl-acetate fraction from a cinnamon-cortex extract protects pancreatic beta-cells from oxidative stress damage. Front Pharmacol (2023) 1111860.
5. Q. You#, J. Qiao#, Q. Peng, W. Li, J. Li, S. Hu, Z. Shu, and B. Sun, HIV-1 Infection Promotes Cholesterol Aggregation by Inducing miR-33b-5p to Suppress ABCA1 Expression. AIDS Res Hum Retroviruses (2023).
6. J. Qiao#, and Q. Liu, Interplay between autophagy and Sindbis virus in cells derived from key arbovirus vectors, Aedes albopictus and Aedes aegypti mosquitoes. Cell Signal (2022) 110204.
7. W. Li#, J. Qiao#, Q. You, S. Zong, Q. Peng, Y. Liu, S. Hu, W. Liu, S. Li, X. Shu, and B. Sun, SARS-CoV-2 Nsp5 Activates NF-kappaB Pathway by Upregulating SUMOylation of MAVS. Front Immunol (2021) 750969.
8. J. Qiao#, Q. Peng#, F. Qian, Q. You, L. Feng, S. Hu, W. Liu, L. Huang, X. Shu, and B. Sun, HIV-1 Vpr protein upregulates microRNA-210-5p expression to induce G2 arrest by targeting TGIF2. PLoS One (2021) e0261971.
9. J. Qiao#, W. Li, J. Bao, Q. Peng, D. Wen, J. Wang, and B. Sun, The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues. Biochem Biophys Res Commun 533 (2020) 867-871.
10. J. Qiao#, D. Zhang, Y. Wang, X. Li, S. Wang, and Q. Liu, Identification of AaAtg8 as a marker of autophagy and a functional autophagy-related protein in Aedes albopictus. PeerJ (2018) e5988.
11. 乔嘉璐#，彭倩，翟莹，李卫玲，孙宾莲, SARS-CoV-2入侵细胞的研究进展. 病毒学报. 2021,37(02).
其他部分参与文章：
1 Jiazheng Guo; WeiLing Li; Mengbing Huang; Jialu Qiao; Pin Wan; Yulin Yao; Lirui Ye; Ye Ding; Jianing Wang; Qian Peng; Wei Liu; Yiyuan Xia; Xiji Shu; Binlian Sun. SARS-CoV-2 Nsp7 plays a role in cognitive dysfunction by impairing synaptic plasticity. Front Neurosci (2024) 1490099.
2 Feng Xiao; Yaling Jia; Simeng Zhang; Nanfang Liu; Xuelong Zhang; Tianci Wang; Jialu Qiao; Ge Yang; Xu Che; Keli Chen; Pan Pan; Lingli Zhou; Binlian Sun; Jun Chen; Pin Wan. SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3. Journal of Biological Chemistry (2024) 107233.
3 Weiling Li; Pin Wan; Jialu Qiao; Yuchen Liu; Qian Peng; Zehua Zhang; Xiji Shu; Yiyuan Xia; Binlian Sun. Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders. Front Pharmacol (2024) 1111860.
4 Song Hu; Zuoyu Shao; Wei Ni; Pan Sun; Jialu Qiao; Hexing Wan; Yi Huang; Xiaolong Liu; Haoyang Zhai; Mingzhong Xiao; Binlian Sun. The KIR2DL2/HLA-C1C1 Gene Pairing Is Associated with an Increased Risk of SARS-CoV-2 Infection. Front Immunol (2022) 919110.
5 Runji Zhang; Jian Bao; Jialu Qiao; Wenshuang Li; Feng Qian; Kanghong Hu; Binlian Sun. Long-term efavirenz exposure induced neuroinflammation and cognitive deficits in C57BL/6 mice. Biochem Biophys Res Commun 584 (2021) 46-52.
6 Wang Yu; Qiao jialu; Zhang Dandan; Zhong Chunyan; Wang Shengya; Li Xiaomei; Feng Lingyan; Shi Shen; Wang Bingxue; Liu Qingzhen. Systematic identification of autophagy-related proteins in Aedes albopictus. PLoS One (2021) e0245694
六、申请与授权专利
1. 乔嘉璐；陈海峰；孙宾莲；舒细记；叶贤胜；王承海. 白藜芦醇三酚 c 在制备抗 SARS-CoV-2 感染药物中的应用. 2022. CN202210446832.0.
2. 孙宾莲；舒细记；龚睿；贺贤然；乔嘉璐；王承海；孙攀；刘钰晨；柳威；李卫玲；彭倩. 一种小分子化合物在制备抗SARS-CoV-2感染药物中的应用. 2022. ZL202211261085.X.
七、招生招聘
欢迎对病毒学研究感兴趣的本科生、研究生、博士生或博士后加入我们课题组! 有意向加入者请将简历发送至jialuqiao@hubu.edu.cn
