一、基本信息
陈明周，博士，二级教授，博士生导师
电子邮件：chenmz@hubu.edu.cn
研究领域：医学病毒学、分子病毒学、新型疫苗及抗病毒药物
研究方向：
聚焦于重要的人类和动物病毒（包括人副流感病毒、呼吸道合胞病毒、寨卡病毒、肠道病毒71型、新冠病毒、埃博拉病毒、尼帕病毒、乙型肝炎病毒等）的感染、复制与致病机制的研究，解析病毒在宿主细胞内的复制、组装、释放及病毒与宿主细胞的相互作用机制；结合结构生物学、生物信息学发现和鉴定新的抗病毒治疗靶点，在筛选传统抗病毒小分子药物的同时还开展包括纳米颗粒疫苗和RNA疫苗在内的多种新型预防和治疗性抗病毒药物的研发。
研究团队：必赢唯一官方网站病毒学和疫苗研究中心，陈明周教授课题组，链接：/info/2059/16972.htm
二、教育背景
1996.09-2002.07 华中农业大学，微生物学，博士学位
1992.09-1996.06 华中农业大学，本科，学士学位
三、工作经历
2023.8至今 必赢集团网站，教授，博士生导师
2019-2023 武汉大学必赢集团网站，副院长
2018-2019 武汉大学必赢集团网站，院长助理
2017-2023 武汉大学病毒学国家重点实验室，副主任
2009-2023 武汉大学必赢集团网站/病毒学国家重点实验室，教授
2005-2009 美国克利夫兰临床医院，分子遗传学系，博士后
2002-2005 法国里昂第一大学感染与免疫学系，博士后
四、科研项目
1. 国家自然科学基金区域联合基金项目：埃博拉和尼帕病毒基质蛋白翻译后修饰调控病毒粒子出芽的分子机制，2025.01-2028.12，260万
2. 国家重点研发计划 “合成生物学” 专项：自组装纳米颗粒广谱疫苗设计与合成， 2024.12-2029.11，550万
3. 国家自然科学基金重点项目“人副流感病毒3型复制细胞器生物合成及功能发挥的分子机制”，2022.01-2026.12，290万
4. 国家重点研发计划“病原学与防疫技术体系研究”专项“病毒复制与宿主相互作用研究及药物靶点发现”，2021.12-2024.11，687万
5. 国家杰出青年科学基金项目“RNA病毒感染和致病的分子机制”，2019.01-2023.12，400万
6. 国家自然科学基金重点项目“人副流感病毒诱导的线粒体自噬及其调控先天免疫和病毒复制的机制”2017.01-2021.12，287万
7. 湖北省重点研发计划“靶向宿主囊泡运输途径关键调节因子RAB11的广谱型抗呼吸道病毒多肽研发”，2023.01-2025.12，100万
8. 国家自然科学基金面上项目“人副流感病毒3型核衣壳蛋白的功能研究” 2015.01-2018.12，100万
9. 国家自然科学基金面上项目“水泡性口炎病毒磷酸蛋白氨基端磷酸化的功能研究”，2013-2016，70万
五、代表性成果
1. Li J, Zhu C, Meng Y, Zhang L, Liu C, Qin Y, Chen M. Zika virus inhibits cell death by inhibiting the expression of NLRP3 and A20. J Virol. 2025 Feb 20: e0198024.
https://doi.org/10.1128/jvi.01980-24
2. Zhang L, Qin Y, Chen M. Flavivirus NS2A orchestrates reticulophagy to enhance viral pathogenicity. Autophagy. 2025 Feb 7:1-2.
https://doi.org/10.1080/15548627.2025.2457112
3. Zhou S, Hui X, Wang W, Zhao C, Jin M, Qin Y, Chen M. SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication. Emerg Microbes Infect. 2025 Dec;14(1):2447620.
https://doi.org/10.1080/22221751.2024.2447620
4. Jin D, Zhang L, Peng C, He M, Wang W, Li Z, Liu C, Du J, Zhou J, Yin L, Shan C, Qin Y, Chen M. The E3 ligase RAD18-mediated ubiquitination of henipavirus matrix protein promotes its nuclear-cytoplasmic trafficking and viral egress. Emerg Microbes Infect. 2025 Dec;14(1):2432344.
https://doi.org/10.1080/22221751.2024.2432344
5. Zhang L, Wang H, Han C, Dong Q, Yan J, Guo W, Shan C, Zhao W, Chen P, Huang R, Wu Y, Chen Y, Qin Y, Chen M. AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity. Nat Commun. 2024 Nov 6;15(1):9578.
https://doi.org/10.1038/s41467-024-54010-w
6. Han Y, Zhou H, Liu C, Wang W, Qin Y, Chen M. SARS-CoV-2 N protein coordinates viral particle assembly through multiple domains. J Virol. 2024 Nov 19;98(11): e0103624.
https://doi.org/10.1128/jvi.01036-24
7. Wu X, Zhang L, Liu C, Cheng Q, Zhao W, Chen P, Qin Y, Chen M. The NS2B-PP1α-eIF2α axis: Inhibiting stress granule formation and Boosting Zika virus replication. PLoS Pathog. 2024 Jun 27;20(6): e1012355.
https://doi.org/10.1371/journal.ppat.1012355
8. Zhang Q, Ye H, Liu C, Zhou H, He M, Liang X, Zhou Y, Wang K, Qin Y, Li Z, Chen M. PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment. Virol Sin. 2024 Apr;39(2):235-250.
https://doi.org/10.1016/j.virs.2023.12.001
9. Li Z, Zheng M, He Z, Qin Y, Chen M. Morphogenesis and functional organization of viral inclusion bodies. Cell Insight. 2023 Apr 12;2(3):100103.
https://doi.org/10.1016/j.cellin.2023.100103
10. Liu P, Zhang S, Ma J, Jin D, Qin Y, Chen M. Vimentin inhibits α-tubulin acetylation via enhancing α-TAT1 degradation to suppress the replication of human parainfluenza virus type 3. PLoS Pathog. 2022 Sep 15;18(9): e1010856.
https://doi.org/10.1371/journal.ppat.1010856
11. Guo D, Yu X, Wang D, Li Z, Zhou Y, Xu G, Yuan B, Qin Y, Chen M. SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection. J Virol. 2022 May 11;96(9): e0204221.
https://doi.org/10.1128/jvi.02042-21
12. Fan S, Xu Z, Liu P, Qin Y, Chen M. Enterovirus 71 2A protease Inhibits P-Body formation to promote Viral RNA synthesis. J Virol. 2021 Sep 9;95(19): e0092221.
https://doi.org/10.1128/jvi.00922-21
13. Zhang L, Zhou S, Chen M, Yan J, Yang Y, Wu L, Jin D, Yin L, Chen M, Qin Y. P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity. PLoS Pathog. 2021 Jun 10;17(6): e1009616.
https://doi.org/10.1371/journal.ppat.1009616
14. Hui X, Zhang L, Cao L, Huang K, Zhao Y, Zhang Y, Chen X, Lin X, Chen M, Jin M. SARS-CoV-2 promote autophagy to suppress type I interferon response. Signal Transduct Target Ther. 2021 May 8;6(1):180.
https://doi.org/10.1038/s41392-021-00574-8
15. Cheng Q, Huai W, Wu X, Chen M. Sumoylation of Human Parainfluenza Virus Type 3 Phosphoprotein Correlates with A Reduction in Viral Replication. Virol Sin. 2021 Jun;36(3):438-448.
https://doi.org/10.1007/s12250-020-00314-2
16. Wu L, Jin D, Wang D, Jing X, Gong P, Qin Y, Chen M. The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding. Protein Cell. 2022 Feb;13(2):120-140.
https://doi.org/10.1007/s13238-020-00764-0
17. Li Z, Guo D, Qin Y, Chen M. PI4KB on Inclusion Bodies Formed by ER Membrane Remodeling Facilitates Replication of Human Parainfluenza Virus Type 3. Cell Rep. 2019 Nov 19;29(8):2229-2242.e4.
https://doi.org/10.1016/j.celrep.2019.10.052
18. Tang Q, Liu P, Chen M, Qin Y. Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3. Viruses. 2019 May 15;11(5):438.
https://doi.org/10.3390/v11050438
19. Zhang Q, Sharma NR, Zheng ZM, Chen M. Viral Regulation of RNA Granules in Infected Cells. Virol Sin. 2019 Apr;34(2):175-191.
https://doi.org/10.1007/s12250-019-00122-3
20. Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y, Chen M. SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Cell Discov. 2019 Jan 1; 5:1.
https://doi.org/10.1038/s41421-018-0068-4
21. Zhang L, Qin Y, Chen M. Viral strategies for triggering and manipulating mitophagy. Autophagy. 2018;14(10):1665-1673.
https://doi.org/10.1080/15548627.2018.1466014
22. Zhang S, Cheng Q, Luo C, Qin Y, Chen M. Human Parainfluenza Virus Type 3 Matrix Protein Reduces Viral RNA Synthesis of HPIV3 by Regulating Inclusion Body Formation. Viruses. 2018 Mar 11;10(3):125.
https://doi.org/10.3390/v10030125
23. Hu Z, Wang Y, Tang Q, Yang X, Qin Y, Chen M. Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs. PLoS Pathog. 2018 Mar 8;14(3): e1006948.
https://doi.org/10.1371/journal.ppat.1006948
24. Zhang S, Cheng Q, Luo C, Yin L, Qin Y, Chen M. An alanine residue in human parainfluenza virus type 3 phosphoprotein is critical for restricting excessive N0-P interaction and maintaining N solubility. Virology. 2018 May; 518:64-76.
https://doi.org/10.1016/j.virol.2018.02.008
25. Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, Qin Y, Chen M. Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. PLoS Pathog. 2018 Feb 7;14(2): e1006901.
https://doi.org/10.1371/journal.ppat.1006901
26. Ding B, Zhang L, Li Z, Zhong Y, Tang Q, Qin Y, Chen M. The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses. Cell Host Microbe. 2017 Apr 12;21(4):538-547.e4.
https://doi.org/10.1016/j.chom.2017.03.004
27. Zhang S, Jiang Y, Cheng Q, Zhong Y, Qin Y, Chen M. Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated α-Tubulin Enhances Viral Replication. J Virol. 2017 Jan 18;91(3): e01802-16.
https://doi.org/10.1128/jvi.01802-16
28. Jiang Y, Qin Y, Chen M. Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity. Viruses. 2016 Nov 16;8(11):308.
https://doi.org/10.3390/v8110308
29. Yan Q, Wu L, Chen L, Qin Y, Pan Z, Chen M. Vesicular stomatitis virus-based vaccines expressing EV71 virus-like particles elicit strong immune responses and protect newborn mice from lethal challenges. Vaccine. 2016 Jul 29;34(35):4196-4204.
https://doi.org/10.1016/j.vaccine.2016.06.058
30. Chen L, Zhong Y, Hu Z, Qin Y, Chen M. Two second-site mutations compensate the engineered mutation of R7A in vesicular stomatitis virus nucleocapsid protein. Virus Res. 2016 Mar 2; 214:59-64.
https://doi.org/10.1016/j.virusres.2016.01.012
31. Ding B, Qin Y, Chen M. Nucleocapsid proteins: roles beyond viral RNA packaging. Wiley Interdiscip Rev RNA. 2016 Mar-Apr;7(2):213-26.
https://doi.org/10.1002/wrna.1326
32. Zhang G, Zhong Y, Qin Y, Chen M. Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly. J Virol. 2015 Dec 9;90(5):2306-15.
https://doi.org/10.1128/jvi.02324-15
33. Chen L, Yan Q, Lu G, Hu Z, Zhang G, Zhang S, Ding B, Jiang Y, Zhong Y, Gong P, Chen M. Several residues within the N-terminal arm of vesicular stomatitis virus nucleoprotein play a critical role in protecting viral RNA from nuclease digestion. Virology. 2015 Apr; 478:9-17.
https://doi.org/10.1016/j.virol.2015.01.021
34. Zhang G, Zhang S, Ding B, Yang X, Chen L, Yan Q, Jiang Y, Zhong Y, Chen M. A leucine residue in the C terminus of human parainfluenza virus type 3 matrix protein is essential for efficient virus-like particle and virion release. J Virol. 2014 Nov;88(22):13173-88.
https://doi.org/10.1128/jvi.01485-14
35. Ding B, Zhang G, Yang X, Zhang S, Chen L, Yan Q, Xu M, Banerjee AK, Chen M. Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production. Cell Host Microbe. 2014 May 14;15(5):564-77.
https://doi.org/10.1016/j.chom.2014.04.004
36. Zhang S, Chen L, Zhang G, Yan Q, Yang X, Ding B, Tang Q, Sun S, Hu Z, Chen M. An amino acid of human parainfluenza virus type 3 nucleoprotein is critical for template function and cytoplasmic inclusion body formation. J Virol. 2013 Nov;87(22):12457-70.
https://doi.org/10.1128/jvi.01565-13
37. Chen L, Zhang S, Banerjee AK, Chen M. N-terminal phosphorylation of phosphoprotein of vesicular stomatitis virus is required for preventing nucleoprotein from binding to cellular RNAs and for functional template formation. J Virol. 2013 Mar;87(6):3177-86.
https://doi.org/10.1128/jvi.02761-12
38. Chen M, Ogino T, Banerjee AK. Interaction of vesicular stomatitis virus P and N proteins: identification of two overlapping domains at the N terminus of P that are involved in N0-P complex formation and encapsidation of viral genome RNA. J Virol. 2007 Dec;81(24):13478-85.
https://doi.org/10.1128/jvi.01244-07
39. Chen M, Gerlier D. Viral hijacking of cellular ubiquitination pathways as an anti-innate immunity strategy. Viral Immunol. 2006 Summer;19(3):349-62.
https://doi.org/10.1089/vim.2006.19.349
40. Chen M, Ogino T, Banerjee AK. Mapping and functional role of the self-association domain of vesicular stomatitis virus phosphoprotein. J Virol. 2006 Oct;80(19):9511-8.
https://doi.org/10.1128/jvi.01035-06
41. Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D. Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein. J Virol. 2005 Sep;79(18):11824-36.
https://doi.org/10.1128/jvi.79.18.11824-11836.2005
