董旭

作者：发布时间：2025-04-10 阅读次数:

一、基本信息

董旭，博士，副教授

电子邮件：dongxu@hubu.edu.cn

研究领域：结构生物学、生物物理

二、教育背景

2007.09–2011.06 英国布里斯托大学，博士

2004.09–2007.06 英国纽卡斯尔大学，学士

三、工作经历

2024.01至今必赢唯一官方网站，必赢集团网站，副研究员

2015.10–2023.12 中国科学院精密测量科学与技术创新研究院，副研究员

2015.06-2015.09 中国科学院武汉物理与数学研究所，助理研究员

2012.06-2015.06 中国科学院武汉物理与数学研究所，博士后

四、主持科研项目

1. 国家自然科学基金青年科学基金项目：处于氧化态的HIV-1衣壳蛋白碳端结构域的结构与生物学意义研究，主持，2015年1月至2017年12月.

2. 国家重点研发计划项目：细胞内蛋白质结构和互作的原位NMR分析新技术与新方法，项目骨干，2017年7月至2022年6月.

3. 国家重点研发计划：蛋白质机器动态结构的核磁共振研究方法及应用，项目骨干，2016年7月至2021年6月.

五、代表性论文（^#第一作者; *通讯作者）

1. Dong, Xu(#*); Xu, Manli(#); Wu, Miao(#); Wang, Ying(#); Cheng, Xiaoqi; Jiang, Wenxue; Zheng, Dule; Omar, Ahmed Habiba; Cheng, Yibin; Li, Aitao; Ma, Lixin; Xing, Qiong(*); Structural and catalytic insights into MhpB: A dioxygenase enzyme for degrading catecholic pollutants, Journal of Hazardous Materials, 2025, 488: 137437 (IF factor: 12.2)

2. Peng Cheng; Yuzhu Hou; Mingxing Bian; Xueru Fang; Yan Liu; Yuanfang Rao; Shuo Cao; Yanjun Liu; Shuai Zhang; Yanke Chen; Xu Dong(*); Zhu Liu(*); Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove, Communications Biology, 2023, 6(1): 1260 (IF factor: 5.2)

3. Ma L, Jia HL, Shen AL, Ding JY, Wang XY, Wang J, Wan JJ, Yan JJ, Zhang DL, Dong X(*), Yin P(*). (2022) Two determinants influence CRY2 photobody formation and function. Plant Biotechnology Journal, 21: 460-462 (IF factor: 13.26)

4. Gong Z, Yang J, Qin LY, Tang C, Jiang HQ, Ke YB, Dong X(*). (2022) Preferential Regulation of Transient Protein-Protein Interaction by the Macromolecular Crowders. J Phys Chem B, 126:4840-4848 (IF factor: 3.47)

5. Dong X, Qin LY, Gong Z, Qin S, Zhou HX, Tang C. (2022) Preferential Interactions of a Crowder Protein with the Specific Binding Site of a Native Protein Complex. J Phys Chem Lett, 13:792-800 (IF factor: 6.89)

6. Qin LY, Gong Z, Liu K, Dong X(*), Tang C(*).（2021）Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors. Biomolecules，11:1008-1020 (IF factor: 6.06)

7. Liu Z(#), Dong X(#), Yi HW(#), Yang J, Gong Z, Wang Y, Liu K, Zhang WP, Tang C. (2019) Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. Cell Discov, 5:19-34 (IF factor: 38.08)

8. Huang JB(#), Dong X(#), Gong Z, Qin LY, Yang S, Zhu YL, Wang X, Zhang DL, Zou TT, Yin P, Tang C. (2019) Solution structure of the RNA recgonition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein & Cell, 10:272-284 (IF factor: 15.33)

9. Ye SX, Gong Z, Yang J, An YXi, Liu Z, Zhao Q, Lescop E, Dong X(*), Tang C(*). (2019) Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch, Protein & Cell, 10:908–913 (IF factor: 15.33)

10. Dong X, Gong Z, Lu YB, Liu K, Qin LY, Ran ML, Zhang CL, Liu Z, Zhang WP, Tang C, Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. PNAS, 2017, 114: 6770-6775 (IF factor: 11.21)

11. Jiang WX, Gu XH, Dong X(*), Tang C(*). (2017) Lanthanoid tagging via an unnatural amino acid for protein structure characterization, Journal of Biomolecular NMR, 67: 273-282 (IF factor： 2.58)

12. Fang G, Luan BQ, Ge CC, Yu C, Dong X(*), Guo J, Tang C, Zhou RH (*) (2017) Understanding the graphene quantum dots-ubiquitin interaction by identifying the interaction sites. Carbon, 112:285-291 (IF factor: 11.31)

13. Dong X; Bailey C, Williams C, Crosby J; Simpson T, Wllis C, Crump M. (2016) Recognition of extended linear and cyclised polyketide mimics by a Type II acyl carrier protein. Chemical Science, 7(3): 1779-1785 (IF factor: 9.97)

14. Haines A(#); Dong X(#), Song ZS, Farmer R, Williams C, Hothersall J, Ploskon E, Wattana-amorn P, Stephens E, Yamada E, Gurney R, Takebayashi Y, Masschelein J, Cox R, Lavigne R, Willis C, Simpson T, Crosby J, Winn P, Thomas C, Crump M. (2013) A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis. Nature Chemical Biology, 11, 9(11): 685-692 (IF factor: 16.17)

六、申请与授权专利